"The Last Psychiatrist." Lots of long thought-provoking essays on medical and conceptual topics. It's good enough that I'm gradually reading through the entire archives (the fact that it avoids short links to yesterday's news helps). Lots of posts are worth pointing to; a few examples would be The Bubble in Academic Research, Off Label Prescribing, Which is Worse, and Where Does a Tree Get Its Mass.
UPDATE: See also Are Drug Companies Hiding Negative Studies?.
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